Nasty malware infection

[Darwock]

My PC is infested and neither AVG nor Ad-aware are picking up anything as being wrong.

The symptoms are:

keystrokes lag severely when typing in IE
google result links take me to completly unrelated pages (usually shop sites)
when I log into ebay I immediately get a second pop-up asking for confirmation of card details - I would have fallen for this except the last entry they wanted was ATM PIN. Yeah right!!

As none of the malware programs are identifying a problem (and having googled it, others have had similarly poor results with other malware utilities) I'm wondering what my choices are.

If I ditch Internet Explorer and start using Chrome or something, would that resolve it? Is it even possible to uninstall IE?

[monel]

Try Spyware Blaster, but more importantly, have you run HijackThis?

Run the latter, and see what it flags as supsicious according to the key/index. Then maybe google the suspicious entries or post them on here and then remove them if they are malicious.

[prinnysquad]

Yep, run Hijack this is safe mode. I've had to do that before and manually remove inserted startup progs. Then try running malwarebytes in safe mode.

[k0pp0]

I had an absolute beast of a virus infection on my pc.. got a lot of very good ideas for fixing it from here: http://forums.majorgeeks.com/showthread.php?t=137630
and here: http://www.geekstogo.com/forum

and this is pretty good too: http://www.eset.com/us/online-scanner

[abigsmurf]

You could be rootkitted in which case it's a nightmare to remove. Infections as bad as what often go alongside a rootkit.

More likely however is that the malware is just interfering with scanners.

Run as many scanners as possible in safemode, post a hijack this log here or on a dedicated forum.

Try renaming the executables for your scanners before running too (most allow it)

[Darwock]

Will do this when I have some time to sit down with it, thanks for the tips so far. If I have to post logs I'll probably do it here, you're a knowledgable lot and I don't like to go too far afield

[Oldgamingfart]

As suggested, try Malwarebyes (in Safe Mode), it's usually pretty effective. Also try a boot scan with Avast (on the Avast menu select 'Scan Computer' > 'Boot-time Scan', then restart).

Disconnect the computer from the Internet once you have all the required software. This will stop the virus from downloading anything else in the background.