The thing about this (multiple playthroughs) is that when the first one came out, you didn't have 4-5 games being released every week that you'd be interested in.
So back then, replaying a game 3-5 times, as I did...it was viable. Doing so for a game like this nowadays with Reach, FIFA and PES on the horizon...I just don't think people will do it.
My advice, for the least stressful time is to enjoy a first playthrough of just story, give yourself plenty of time to always be able to go the case files, level up as best you can along the way. Second time, do what you want, but knowing the way the case files go you will find it far more enjoyable the second time.
Some of the bosses are beasts though and you'll be best to avoid them until the second playthrough.
So back then, replaying a game 3-5 times, as I did...it was viable. Doing so for a game like this nowadays with Reach, FIFA and PES on the horizon...I just don't think people will do it.
My advice, for the least stressful time is to enjoy a first playthrough of just story, give yourself plenty of time to always be able to go the case files, level up as best you can along the way. Second time, do what you want, but knowing the way the case files go you will find it far more enjoyable the second time.
Some of the bosses are beasts though and you'll be best to avoid them until the second playthrough.
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