I just got through this on the 360, I played nothing else for a good solid month so prepare to be taken over!
I think lockpick, science and speech are good ones to level up quite early as that'll help you with the respective achievements/trophies and finding a locked door or computer that you're not skilful enough to open/hack is annoying.
After those I mainly concentrated on weapon stats. Oh and repair as well, I didn't boost that early which made it harder to keep my weapons in good condition. Worrying about boosting the wrong stats is something I do during games like this and Oblivion too, but I don't think you can go too far wrong just playing it by ear.
I think lockpick, science and speech are good ones to level up quite early as that'll help you with the respective achievements/trophies and finding a locked door or computer that you're not skilful enough to open/hack is annoying.
After those I mainly concentrated on weapon stats. Oh and repair as well, I didn't boost that early which made it harder to keep my weapons in good condition. Worrying about boosting the wrong stats is something I do during games like this and Oblivion too, but I don't think you can go too far wrong just playing it by ear.
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